Unicorn Tapestries, Horned Animals, and Prion Disease

" The written text is a recent form of textile, ancillary to those primary texts 'told' or 'tooled' in cloth " (1). Thousands of years before humans could write, they could weave, turning cloth into a commodity, symbol of wealth, and decorative art. In many cultures, weaving has become a common linguistic metaphor as " weave " is used broadly to mean " create. " A weaver " not only fashions textiles but can, with the same verb, contrive texts " (2). Textiles, which date back to the Neolithic and Bronze Ages, have strong egalitarian roots and an ancient connection with personal expression (3). The primary purpose of weaving was storytelling. In Greek mythology, skilled Arachne challenged Athena, the goddess of wisdom and patron of the loom, to a contest. Arachne wove an elaborate account of the scandalous lives of gods and won respect from the judges but wrath from Athena, who turned her into a spider. In 11th-century France, unknown weavers stitched the conquest of England on 70 meters of linen in the Bayeux Tapestry. Countless techniques and styles of weaving evolved throughout the ages, producing imaginative designs through a tactile process (4). In the Middle Ages, represen-tational and other scenes commissioned by wealthy patrons and composed in tapestry workshops all over Europe decorated and insulated large structures (5). Luxurious wool, silk, and other threads were used in massive tapestries depicting love of nature and the outdoors; a penchant for luxury; and a desire to communicate, shown in banners, initials , and other messages encrypted on the scenes. The Unicorn Is Found, on this month's cover of Emerging Infectious Diseases, is one of seven famed tapestries depicting the Hunt of the Unicorn. The works are housed at The Cloisters, a part of the Metropolitan Museum of Art, New York, designed specifically to evoke the context in which these and other medieval artifacts were created (6). The brilliant descriptions in these tapestries of exotic plants and animals, local customs, and human endeavor document a thriving arts scene in an era often labeled the " Dark Ages. " The tapestries, whose origins and history are as mysterious and enigmatic as their designs, could have belonged to Anne of Brittany, who married King Louis XII in 1499 (6). All tapestries prominently display the cipher AE and have a unifying theme: the struggle between humans and the unicorn. This creature, whose mythologic origins …